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KMID : 0378019920350020098
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New Medical Journal
1992 Volume.35 No. 2 p.98 ~ p.102
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Clinical Effect of Pefloxacin for the Treatment of the Post-operative Infection in Orthopaedic Field.
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Abstract
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The postoperative infection in orthopaedic field has been a quite difficult to be cured. And it required continuous antibiotics therapy or re-operation. Pefloxacin, anew generation of quinolones, is of interest for their broad spectra of antibacterial action, less adverse effect, good distribution volume and excellent bioavailability.
Pefloxacin was evaluated in the treatment of the postoperative infection in orthopaedic field for five months at the department of orthopaedic surgery, National Medical Center. The results were as follows
1. A clinical trial was performed in 15 patients with postoperative infection, i.e. 7 cases with open fix., 4 cases with chronic osteomyelitis, 3 cases with secondary infection and 1 case with bed sore.
2. In 15 patients with the postoperative infection, the result were excellent and good in 13 patients (87%).
3. In bacterial eradication, 6 cases out of 7 cases of S. aureus, 3 cases out of 4 cases of P. aeruginosa, all cases of Enterobacter cloaca, Acinetobacter calcoaceticus were eradicated, but 1 case of P. aeruginosa and 1 case of Serratia marcescens were persisted.
4. During treatment, 3 patients showed adverse reactions, i.e. 2 cases of nausea, I case of diarrhea, but these adverse reactions were not severe enough to stop the treatment.
5. There were no deleterious effect on peripheral blood count, liver and renal function.
In conclusion, Pefloxacin is a safe and effective antibiotics that can be used effectively in the treatment of postoperative infection in orthopaedic surgery. But more strict long-term follow-up should be studied in future.
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